ANTIFOSFOLIPID SINDROM PDF

Patogenesis. Sindrom antibodi antifosfolipid merupakan gangguan autoimun yang ditandai dengan antibodi dalam sirkulasi yang melawan fosfolipid membran. SAPPORO CRITERIA Sindrom antifosfolipid haruslah memenuhi kriteria yang diputuskan oleh para ahli pada simposium internasional ke-8 tentang antibodi. Posts – See Instagram photos and videos from ‘antifosfolipid’ hashtag. ➡ ️Antifosfolipid sindrom və hamiləlik⬅ Antifosfolipid sindrom venoz və ya arterial .

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Majalah Kedokteran Indonesia,46 8 Antiphospholipid syndrome Synonyms Hughes syndrome [1] Micrograph showing an advanced thrombotic microangiopathyas may be seen in ALPA syndrome. The exact cause is not known, but activation of the system atifosfolipid coagulation is evident.

Risk factors for developing antiphospholipid syndrome include: Thus genetic thrombophilia screening can consist of:. Presence of genetic thrombophilia may determine the need for anticoagulation therapy.

This page was last edited on 17 Novemberat Archived PDF from the original on Antiphospholipid syndrome can be primary or secondary. There is an additional elevated risk of adrenal gland bleeds antifosfollpid to Waterhouse—Friderichsen syndrome Neisseria meningitidis caused primary adrenal insufficiency.

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Other common findings, although not part of the APS classification criteria, are low platelet countheart valve diseaseand livedo reticularis. Lupus anticoagulant LAC antibodies bind to prothrombinthus increasing its cleavage to thrombinits active form. The primary mission of APS ACTION is to antifosrolipid, treat, and cure antiphospholipid antibody aPL associated clinical manifestations through high quality, multicenter, and multidisciplinary clinical research.

Antiphospholipid syndrome was described in full in the s, by Nigel Harris and Aziz Gharavi. The antibodies may be just ‘marker’ of the disorder, and thrombosis and pregnancy loss may results from unknown factors which induce a proagulant state. D ICD – In pregnant women affected by APS, there is antifosfolippid increased risk of recurrent miscarriageintrauterine growth restrictionand sindrlm birth. Women with recurrent miscarriage are often advised to take aspirin and to start low molecular weight heparin treatment after missing a menstrual cycle.

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APS provokes blood clots thrombosis in both arteries and veins as well as pregnancy-related complications simdrom as miscarriagestillbirthpreterm deliveryand severe preeclampsia.

Antiphospholipid syndrome – Wikipedia

Antiphospholipid syndrome APS is a disorder of recurrent vascular thrombosis, pregnancy losses and thrombocytopenia associated with persistently elevated levels of antiphospholipid antibodies APA. Coagulopathies Rheumatology Sihdrom diseases Neurological disorders Obstetrics Syndromes affecting blood Syndromes affecting the nervous system.

The American Journal of the Medical Sciences. The Johns Hopkins Lupus Center. VDRL, which detects antibodies against syphilis, may have a false positive sindgom in aPL-positive patients aPL bind to the lipids in the test and make it come out positivealthough the more specific test for syphilis, FTA-Abs, that use recombinant antigens will not have a false-positive result.

Antiphospholipid syndrome

In refractory cases plasmapheresis may anitfosfolipid used. There are 3 distinct APS disease entities: The patient on initial screening will typically have been found to have a prolonged APTT that does not correct in an The syndrome can be divided into primary no underlying disease state and secondary in association with an underlying disease state forms.

The presence of antiphospholipid antibodies aPL in the absence of blood clots or pregnancy-related complications does not indicate APS see below for the diagnosis of APS. The management antfosfolipid venous or arterial thrombosis in patients with APS is no different from that of other patients with antiosfolipid complications.

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Archived copy as title Infobox medical condition new All articles with unsourced statements Articles with unsourced statements from October Articles antifpsfolipid unsourced statements from January There are also associations between antiphospholipid antibodies and headachesmigrainesand oscillopsia.

The Sapporo APS classification criteriapublished in were replaced by the Sydney criteria in Primary antiphospholipid syndrome occurs in the absence of any other related disease. Antiphospholipid syndrome or antiphospholipid antibody syndrome APS or APLSis an autoimmunehypercoagulable state caused by antiphospholipid antibodies.

Antiphospholipid Syndrome (Sindrom Antibodi Antifosfolipid)

In APS patients, the most common venous event is deep vein thrombosis of the lower extremities, and the most common arterial event is stroke. This is to prevent patients with transient positive tests due to infection etc.

Like many autoimmune diseasesit is more common in women than in men. The goal of the prophylactic treatment with warfarin is to maintain the patient’s INR between 2. However, since APS patients appear more subject to recurrent events, prophylactic treatment is recommended for a prolonged period of time. Clinically important antiphospholipid antibodies those that arise as a result of the autoimmune process are associated with thrombosis and vascular disease. Diseases of clotting D50—69,74— Thus, anti-protein S xindrom decrease protein C efficiency.

The diagnostic criteria require one clinical skndrom i. Thus, anti-annexin A5 antibodies increase phospholipid-dependent coagulation steps. Hypo- coagulability Thrombocytopenia Thrombocytopenic purpura: